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Empirical Reports with Relevant Reviews and Commentaries

Click here to download a PDF detailing all the research on the Truehope Formulation.


  1. Rucklidge, J. J., Frampton, C., Gorman, B., & Boggis, A. (2014 May 7). Vitamin-mineral treatment of ADHD in adults: A one year follow up of a randomized controlled trial. Journal of Attention Disorders. ePub.
  2. Julia J. Rucklidge*, Neville Blampied, Brigette Gorman, Heather A. Gordon and Ellen Sole. Psychological functioning 1 year after a brief intervention using micronutrients to treat stress and anxiety related to the 2011 Christchurch earthquakes: a naturalistic follow-up. Hum. Psychopharmacol Clin Exp (2014) DOI:10.1002/hup.2392
  3. Rucklidge JJ., Frampton CA., Gorman B., and Boggis A. Vitamin-Mineral treatment of attention-deficit hyperactivity disorder in adults: double-blind randomized placebo-controlled trial. The British Journal of Psychiatry 1-10.doi: 10.1192/bjp. 113.132126
  4. Rucklidge JJ., Johnstone J., Gorman B., Boggis A. and Frampton CA. Moderators of treatment response in adults with ADHD treated with a vitamin-mineral supplement. Prog Neuro-Psychopharmacol Biol Psychiatry (2013) http://dx.doi.org/10.1016/j.pnpbp.2013.12.014
  5. Rucklidge JJ. Could Yeast Infections Impair Recovery From Mental Illness? A case study Using Micronutrients and Olive Leaf Extract for the Treatment of ADHD and Depression. ADVANCES SUMMER 2013. VOL. 27. NO 3.
  6. Frazier EA, Gracious B, Arnold LE, Failla M, Chitchumroonchokchai C, Habash D, and Fristad MA. Nutritional and Safety Outcomes from an Open-Label Micronutrient Intervention for Pediatric Bipolar Spectrum Disorders. Journal of Child and Adolescent Psychopharmacology
  7. Harrison R, Rucklidge JJ, Blampied N. Use of micronutrients attenuates cannabis and nicotine abuse as evidenced from a reversal design: A case study. Journal of Psychoactive Drugs (in press).
  8. Rodway M, Vance A, Watters A, Lee H, Bos E, Kaplan BJ (2012), Efficacy and cost of micronutrient treatment of childhood psychosis. BMJ Case Reports, 2012 Nov 9. doi:10.1136/bcr-2012-007213. http://casereports.bmj.com/sevendays?fdate=11/05/2012&tdate=11/11/2012
  9. Rucklidge JJ, Andridge R, Gorman B., Blampied N, Gordon H. & Boggis A. (2012). Shaken but unstirred? Effects of micronutrients on stress and trauma after an earthquake: RCT evidence comparing formulas and doses. Hum Psychopharmacol Clin Exp. 27(5):440-54.
  10. Frazier EA, Fristad MA, Arnold LE (2012). Feasibility of a nutritional supplement as treatment for pediatric bipolar spectrum disorders. Journal of Alternative and Complementary Medicine, 18(7):678-685.
  11. Rucklidge JJ, Johnstone J, Harrison R (2011). Can micronutrients improve neurocognitive functioning in adults with ADHD and severe mood dysregulation? A pilot study: A pilot study. Journal of Alternative and Complementary Medicine, 17(12):1-7.
  12. Rucklidge JJ, Blampied NM (2011). Post-earthquake psychological functioning in adults with Attention-Deficit/Hyperactivity Disorder: Positive effects of micronutrients on resilience. New Zealand Journal of Psychology, 40(4):51-57.
  13. Rucklidge JJ, Johnstone J, Harrison R & Boggis A (2011). Micronutrients reduce stress and anxiety following a 7.1 earthquake in adults with Attention-Deficit/Hyperactivity Disorder. Psychiatry Research, 189:281-87. doi:10.1016/j.psychres.2011.06.016 http://www.ncbi.nlm.nih.gov/pubmed/21802745
  14. Simpson JSA, Crawford SG, Goldstein ET, Field C, Burgess E, Kaplan BJ (2011).Systematic review of safety and tolerability of a complex micronutrient formula used in mental health. BMC Psychiatry. 11:62. http://www.biomedcentral.com/content/pdf/1471-244X-11-62.pdf
  15. Rucklidge JJ, Taylor MR, Whitehead KA (2011). Effect of micronutrients on behaviour and mood in adults with ADHD: Evidence from an 8-week open label trial with natural extension. Journal of Attention Disorders. 2011;15(1):79-91.
  16. Rucklidge JJ, Gately D, Kaplan BJ (2010). Database analysis of children and adolescents with Bipolar Disorder consuming a micronutrient formula. BMC Psychiatry, 10:74. http://www.biomedcentral.com/content/pdf/1471-244X-10-74.pdf
  17. Rucklidge JJ & Harrison (2010). Successful treatment of Bipolar Disorder II and ADHD with a micronutrient formula: A case study. CNS Spectrums. 15(5):231-237.
  18. Mehl-Madrona L, Leung B, Kennedy C, Paul S, Kaplan BJ (2010). Micronutrients versus standard medication management in autism: A naturalistic case-control study. Journal of Child and Adolescent Psychopharmacology. 20(2): 95-103. http://www.liebertonline.com/doi/pdfplus/10.1089/cap.2009.0011
  19. Gately, D., Kaplan, B.J. (2009). Database analysis of adults with bipolar disorder consuming a micronutrient formula. Clinical Medicine Insights: Psychiatry. 4:3-16. http://la-press.com/article.php?article_id=1384
  20. Rucklidge, J. J. (2009). Successful treatment of OCD with a micronutrient formula following partial response to CBT: A case study. Journal of Anxiety Disorders, 23: 836–840.
  21. Frazier, E.A., Fristad, M., Arnold, L.E. (2009). Multinutrient Supplement as Treatment: Literature Review and Case Report of a 12-year-old Boy with Bipolar Disorder. Journal of Child and Adolescent Psychopharmacology, 19:453-460.
  22. Kaplan, B.J., Fisher, J.E., Crawford, S.G., Field, C.J., Kolb, B. (2004). Improved mood and behavior during treatment with a mineral-vitamin supplement: An open-label case series of children. Journal of Child and Adolescent Psychopharmacology, 14(1), 115-122.
  23. Kaplan, B. J., Crawford, S. G., Gardner, B., & Farrelly, G. (2002). Treatment of mood lability and explosive rage with minerals and vitamins: Two case studies in children. Journal of Child and Adolescent Psychopharmacology, 12(3), 203-218.
  24. Simmons, M. (2003). Nutritional approach to bipolar disorder (Letter). Journal of Clinical Psychiatry, 64, 338.
  25. Popper, C. W. (2001). Do vitamins or minerals (apart from lithium) have mood-stabilizing effects? [Commentary]. Journal of Clinical Psychiatry, 62, 933-935.
  26. Kaplan, B. J., Simpson, J. S. A., Ferre, R. C., Gorman, C., McMullen, D., & Crawford, S. G. (2001). Effective mood stabilization in bipolar disorder with a chelated mineral supplement. Journal of Clinical Psychiatry, 62, 936-944.

Review articles, and Others Relevant to Broad Spectrum Micronutrient Treatment

  1. Rucklidge, J. J., Harris, A., & Shaw, I. (2014). Are the amounts of vitamins in commercially available dietary supplement formulations relevant for the management of psychiatric disorders in children? New Zealand Journal of Medicine, 127, 73-85.
  2. Rucklidge JJ & Kaplan BJ (2013). Broad-spectrum micronutrient formulas for the treatment psychiatric symptoms: A systematic review. Expert Review of Neurotherapeutics, 13(1):49-73.
  3. Rucklidge, J. J., & Kaplan, B. J. (2014). Broad Spectrum Micronutrient Treatment for Attention-Deficit/Hyperactivity Disorder: Rationale, and Evidence to Date. CNS Drugs, 28(9), 775-785.
  4. Rucklidge JJ, Johnstone J, Kaplan BJ (2013). Magic bullet thinking--why do we continue to perpetuate this fallacy? (Letter). British Journal of Psychiatry, 203(2):154.
  5. Kaplan BJ, Leung B (2011). Micronutrient treatment of mental disorders. Integrative Medicine: A Clinician’s Journal, 10(3):32-39.
  6. Shaw I, Rucklidge JJ, Hughes RN (2010). A possible biological mechanism for the B Vitamins altering behaviour in ADHD. Pharmaceutical Medicine, 24 (5): 1-6.
  7. Gardner A, Kaplan BJ, Rucklidge JJ, Jonsson BH, Humble MB (2010). The potential of nutritional therapy (Letter). Science, 327(5963):268.
  8. Rucklidge JJ, Johnstone J, Kaplan JJ (2009). Nutrient supplementation approaches in the treatment of ADHD. Expert Review of Neurotherapeutics, 9(4), 461-476.
  9. Kaplan BJ, Crawford S, Field C, and Simpson JSA. (2007). Vitamins, minerals, and mood. Psychological Bulletin, 133(5), 747-760.
  10. Kaplan BJ and Shannon, S (2007). Nutritional aspects of child and adolescent psychopharmacology. Psychiatric Annals, 37(7), 519-528. (reprinted in Pediatrics Annals, 36(9), 600-609).
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